高承源 副研究員

Cheng-Yuan Kao                                                                             Profile updated: August 26, 2019

Associate Investigator                                                                                     ResearcherID: A-7531-2010

Immunology Research Center, National Health Research Institutes

[Contact Information]

Phone   +886-37-206166 Ext 37622

Fax        +886-37-586642

Email     chengyuankao@nhri.edu.tw

Address  35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)

Specialty/keyword

Microbiota / Systems biology / Gut barrier and mucosal immunity / Inflammatory diseases (obesity, metabolic diseases, colitis) / DUSP / C. elegans innate immunity / Pore-forming toxin / Statin biology

Research Interests

Our current direction of research is focusing on studying inflammatory diseases such as obesity/metabolic disorders (e.g. nonalcoholic fatty liver diseases) and colitis. My lab has discovered that the gut microbiota could mediate the resistance in diet-induced obesity in dusp6 knockout mouse model. I believe that integration is the key in the research of this era. We aim to apply integrative approaches to investigate biology of inflammation and its associated diseases from molecules to the whole organisms. Currently we are trying to combine a multi-omics (single-cell and bulk transcriptomics, proteomics, metabolomics and microbiome/metagenome) strategy and complementary in vitro and in vivo mechanistic approaches to study the roles of low-level inflammation and host microbiota play in metabolic and inflammatory diseases.

Education History

  • 1990-1994 B.S. in Biology National Cheng-Kung University, Tainan, Taiwan.
  • 1994-1996 M.S. in Genetics  National Yang-Ming University, Taipei, Taiwan.
  • 2000-2005 Ph.D. in Genetics  University of California – Davis, Davis, CA, USA.

Professional Position

  • 1998-2000 Research Assistant, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • 2005-2010 Postdoctoral Researcher, Section of Cell and Developmental Biology, University of California – San Diego, La Jolla, CA, USA.
  • 2010-2011 Postdoctoral Researcher, Department of Internal Medicine, University of California – Davis, Davis, CA, USA.
  • 2011-2012 Assistant Project Scientist, Department of Internal Medicine, University of California – Davis, Davis, CA, USA.
  • 2012-2017 Assistant Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
  • 2017-present Associate Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

Honors and Awards

  • 08/2017-07/2020 Project for Excellent Junior Research Investigators (MOST-106-2628-B-400-001-MY3).
  • 07/2010-06/2011 Ruth L. Kirschstein National Research Service Award (T32-HL-07013).
  • 05/2005 Graduate Student Travel Award, University of California, Davis.
  • 07/2001-09/2001 Summer Research Assistantship / Engineering or Computer-related Applications and Methods, University of California, Davis.

Provisional Applications and Patents 

  • Anti-Obesity Microbiota Compositions and Preparation Methods and Uses There of. Inventors: Jhen-Wei Ruan and Cheng-Yuan Kao. Taiwan: Application No. 106112695 and PCT: Application No. PCT/US17/27599

Professional Membership

  • 2006, 2012 The American Society for Cell Biology (ASCB).
  • 2007-2009 Genetics Society of America (GSA).
  • 2004-2005 American Thoracic Society (ATS).

Publications

  1. I-Ching Ho, Ling-Huei Yih, Cheng-Yuan Kao and Te-Chang Lee. Tin-protophorin potentiates arsenite-induced DNA strand breaks, chromatid breaks and kinetochore-negative micronuclei in human fibroblasts. Mutation Research 2000 Jul 20; 452(1): 41-50.
  2. Cheng Yuan Kao, Yin Chen, Yu Hua Zhao and Reen Wu. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. American Journal of Respiratory Cell and Molecular Biology 2003 Jul; 29(1):71-80.
  3. Cheng-Yuan Kao, Yin Chen, Philip Thai, Shinichiro Wachi, Fei Huang, Christy Kim, Richart W. Harper and Reen Wu. Interleukin-17 markedly up-regulates beta-defensin 2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. The Journal of Immunology 2004 Sep 1; 173(5): 3482-3491.
  4. Richart W. Harper, Changhong Xu, Jason P. Eiserich, Yin Chen, Cheng-Yuan Kao, Philip Thai, Henny Setiadi and Reen Wu. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Letters 2005 Aug 29; 79(21): 4911-4917.
  5. Cheng-Yuan Kao, Fei Huang, Yin Chen, Philip Thai, Shinichiro Wachi, Christy Kim, Lucinda Tam, and Reen Wu. Up-regulation of CC Chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. The Journal of Immunology 2005 Nov 15; 175(10): 6676-6685.
  6. Reen Wu, Richart W. Harper, Cheng-Yuan Kao, Philip Thai, Daphne Wu, Yin Chen, and Mary M. J. Chang. New insights into airway mucous cell differentiation. Journal of Organ Dysfunction 2006 Mar; 2(1): 30-36.
  7. Fei Huang, Cheng-Yuan Kao, Shinichiro Wachi, Philip Thai, Jisu Ryu, and Reen Wu. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. The Journal of Immunology 2007, Nov 15; 179(10): 6504-6513.
  8. Cheng-Yuan Kao, Christy Kim, Fei Huang, and Reen Wu. Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. The Journal of Biological Chemistry 2008 May 30; 283(22): 15309-15318.
  9. Fei Huang, Cheng-Yuan Kao, Philip Thai, Shinichiro Wachi, Christy Kim, Yong Lee, Li-Yin Hung, Richart Harper, Mary Mann-Jong Chang, and Reen Wu. Regulation of mucosal immunity by airway epithelium: The IL-17A paradigm. Journal of Organ Dysfunction 2008 Jun; 4(2): 93-98.
  10. Larry J. Bischof, Cheng-Yuan Kao, Ferdinand C. O. Los, Manuel R. Gonzalez, Zhouxin Shen, Steven P. Briggs, F. Gisou van der Goot, and Raffi V. Aroian. Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathogens 2008 Oct 10; 4(10): e1000176.
  11. Cheng-Yuan Kao, Ferdinand C. O. Los, and Raffi V. Aroian. Nervous about immunity: neuronal signals control innate immune system. Nature Immunology 2008 Dec; 9(12): 1329-1330.
  12. Audrey Bellier, Chang-Shi Chen, Cheng-Yuan Kao, Hediye N. Cinar, and Raffi V. Aroian. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. PLoS Pathogens 2009 Dec 11; 5(12): e1000689.
  13. Chang-Shi Chen, Audrey Bellier, Cheng-Yuan Kao, Ya-Luen Yang, Huan-Da Chen, Ferdinand C. O. Los, and Raffi V. Aroian. WWP-1 is a novel signal modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS One 2010 Mar 2; 5(3): e9494.
  14. Ferdinand C.O. Los, Cheng-Yuan Kao, Jane Smitham, Kent L. McDonald, Christine Ha, Christina A. Peixoto, and Raffi V. Aroian. RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Cell Host & Microbe 2011 Feb 17; 9(2):147-57.
  15. Cheng-Yuan Kao, Ferdinand C. O. Los, Danielle Huffman, Shinichiro Wachi, Nicole Kloft, Matthias Husmann, Valbona Karabrahimi, Jean-Louis Schwartz, Audrey Bellier, Christine Ha, Youn Sagong, Hui Fan, Partho Ghosh, Mindy Hsieh, Chih-Shen Hsu, Li Chen, and Raffi V. Aroian. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathogens 2011 Mar 3; 7(3): e1001314.
  16. Sarah Statt, Jhen-Wei Ruan, Li-Yin Hung, Ching-Yun Chang, Chih-Ting Huang, Jae Hyang Lim, Jian-Dong Li, Reen Wu, and Cheng-Yuan Kao*. Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2015 Nov;53(5):689-702..
  17. Sarah Statt, Jhen-Wei Ruan, Chih-Ting Huang, Reen Wu and Cheng-Yuan Kao*. Lipidome and transcriptome profiling of pneumolysin intoxication identifies networks involved in statin-conferred protection of airway epithelial cells. Scientific Reports 2015 May 29;5:10624.
  18. Chao-Yang Lai, Da-Wei Yeh, Chih-Hao Lu, Yi-Ling Liu, Li-Rung Huang, Cheng-Yuan Kao, Huan-Yuan Chen, Chi-Ying F. Huang, Chung-Hsing Chang, Yunping Luo, Rong Xiang, and Tsung-Hsien Chuang. Identification of Thiostrepton as a novel inhibitor for psoriasis-like inflammation induced by TLR7-9. The Journal of Immunology 2015 Oct 15;195(8):3912-21.
  19. Jhen-Wei Ruan, Sarah Statt, Chih-Ting Huang, Yi-Ting Tsai, Cheng-Chin Kuo, Hong-Lin Chan, Yu-Chieh Liao, Tse-Hua Tan and Cheng-Yuan Kao*. Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice. Nature Microbiology. 2016 Nov 28;2:16220.
  20. Huan-Da Chen, Cheng-Yuan Kao, Bang-Yu Liu, Shin-Whei Huang, Cheng-Ju Kuo, Jhen-Wei Ruan, Yen-Hung Lin, Cheng-Rung Huang, Yu-Hung Chen, Horng-Dar Wang, Raffi V. Aroian and Chang-Shi Chen. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 2017 Feb;13(2):371-385.
  21. Wei-Chan Hsu, Ming-Yu Chen, Shu-Ching Hsu, Li-Rung Huang, Cheng-Yuan Kao, Wen-Hui Cheng, Chien-Hsiung Pan, Ming-Sian Wu, Guann-Yi Yu, Ming-Shiu Hung, Chuen-Miin Leu, Tse-Hua Tan, and Yu-Wen Su. DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 7. pii: 20180007.
  22. Cherng-Shyang Chang, Jhen-Wei Ruan, and Cheng-Yuan Kao*. An overview of microbiome based strategies on anti-obesity. The Kaohsiung Journal of Medical Sciences. 2019 Jan;35(1):7-16.
  23. Cherng-Shyang Chang and Cheng-Yuan Kao*. Current understanding of the gut microbiota shaping mechanisms. Journal of Biomedical Science. 2019 Aug 21;26(1):59.

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