高承源 副研究員

Cheng-Yuan Kao                                                                             Profile updated: March 13, 2020

Associate Investigator                                                                                     ResearcherID: A-7531-2010

Immunology Research Center, National Health Research Institutes


[Contact Information]

Phone   +886-37-206166 Ext 37622

Fax        +886-37-586642

Email     chengyuankao@nhri.edu.tw

Address  35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)


Specialty/keyword

Microbiota / Systems biology / Gut barrier and mucosal immunity / Inflammatory diseases (obesity, metabolic diseases, colitis) / DUSP / C. elegans innate immunity / Pore-forming toxin / Statin biology

Research Interests

Our current direction of research is focusing on studying inflammatory diseases such as obesity/metabolic disorders (e.g. nonalcoholic fatty liver diseases) and colitis. My lab has discovered that the gut microbiota could mediate the resistance in diet-induced obesity in dusp6 knockout mouse model. I believe that integration is the key in the research of this era. We aim to apply integrative approaches to investigate biology of inflammation and its associated diseases from molecules to the whole organisms. Currently we are trying to combine a multi-omics (single-cell and bulk transcriptomics, proteomics, metabolomics and microbiome/metagenome) strategy and complementary in vitro and in vivo mechanistic approaches to study the roles of low-level inflammation and host microbiota play in metabolic and inflammatory diseases.

Education History

  • 1990-1994 B.S. in Biology National Cheng-Kung University, Tainan, Taiwan.
  • 1994-1996 M.S. in Genetics  National Yang-Ming University, Taipei, Taiwan.
  • 2000-2005 Ph.D. in Genetics  University of California – Davis, Davis, CA, USA.

Professional Position

  • 1998-2000 Research Assistant, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • 2005-2010 Postdoctoral Researcher, Section of Cell and Developmental Biology, University of California – San Diego, La Jolla, CA, USA.
  • 2010-2011 Postdoctoral Researcher, Department of Internal Medicine, University of California – Davis, Davis, CA, USA.
  • 2011-2012 Assistant Project Scientist, Department of Internal Medicine, University of California – Davis, Davis, CA, USA.
  • 2012-2017 Assistant Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
  • 2017-present Associate Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

Honors and Awards

  • 08/2017-07/2020 Project for Excellent Junior Research Investigators (MOST-106-2628-B-400-001-MY3).
  • 07/2010-06/2011 Ruth L. Kirschstein National Research Service Award (T32-HL-07013).
  • 05/2005 Graduate Student Travel Award, University of California, Davis.
  • 07/2001-09/2001 Summer Research Assistantship / Engineering or Computer-related Applications and Methods, University of California, Davis.

Provisional Applications and Patents 

  • Anti-Obesity Microbiota Compositions and Preparation Methods and Uses There of. Inventors: Jhen-Wei Ruan and Cheng-Yuan Kao. Taiwan: Application No. 106112695 and PCT: Application No. PCT/US17/27599

Professional Membership

  • 2006, 2012 The American Society for Cell Biology (ASCB).
  • 2007-2009 Genetics Society of America (GSA).
  • 2004-2005 American Thoracic Society (ATS).

Publications

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