譚澤華 特聘研究員暨主任

Tse-Hua Tan 譚澤華 特聘研究員暨主任                 Profile updated: June. 3, 2019

Distinguished Investigator and Director                                                   Researcher ID: E-3983-2010

Immunology Research Center, National Health Research Institutes    ORCID: 0000-0003-4969-3170 


[Contact Information]

Phone      +886-37-206166 Ext. 37601

Fax            +886-37-586642

Email        ttan@nhri.edu.tw

Address  3F, Bldg R1, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)


SPECIALITY & RESEARCH FIELD OF INTEREST

Protein Kinases and Phosphatases in T-cell Signaling, Autoimmunity, and Inflammation-induced Diseases

Tse-Hua Tan has made significant contributions to the research fields of cancer research, signal transduction, and T cell-mediated diseases. He made a seminal discovery that mutations of the tumor suppressor gene p53 lead to the activation of its oncogenic activity. In particular, Dr. Tan’s group is among the first to demonstrate the critical role of JNK in apoptosis. His highly cited paper in 1996 is the first report indicates that sustained activation of JNK is responsible for apoptosis. Dr. Tan’s team has cloned and characterized multiple novel signaling molecules particularly MAP4K family kinases (HPK1/MAP4K1, GLK/MAP4K3, HGK/MAP4K4) and protein phosphatases (JKAP/DUSP22, DUSP14, PP4) that regulate the JNK-MAPK cascade. Dr. Tan’s current research focuses on studying the roles of MAP4K family kinases and DUSP family phosphatases in T-cell signaling and inflammation-induced human diseases, particularly autoimmune diseases, cancer, and type 2 diabetes.

EDUCATIONS AND POSITIONS 

  • 1980                    B.S. in Chemistry, National Taiwan University, Taipei, Taiwan
  • 1987                    Ph.D. in Molecular Biology (Arnold J. Levine’s Lab), Princeton University, Princeton, New Jersey, USA
  • 1987-1989         Postdoctoral Fellow (Robert G. Roeder’s Lab), The Rockefeller University, New York, New York, USA
  • 1989-1992         Principal Investigator, Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research & Development Center, Frederick, Maryland, USA
  • 1992-1997          Assistant Professor, Department of Microbiology & Immunology, Baylor College of Medicine, Houston, Texas USA
  • 1997-2000         Associate Professor (tenured), Department of Microbiology & Immunology, Baylor College of Medicine, Houston, Texas USA
  • 2000-present  Professor (tenured), Department of Immunology (renamed as Dept. of Pathology & Immunology since 2009), Baylor College of Medicine, Houston, Texas USA
  • 2003-2013         Director, NIH Training Program in Immunology, Baylor College of Medicine, Houston, Texas USA
  • 2014-2015          Chair Professor (joint appointment), Graduate Institute of Immunology, China Medical University, Taiwan
  • 2014-2015          Honorary Director (joint appointment), Research and Development Center for Immunology, China Medical University, Taiwan
  • 2000-present   Professor (tenured), Department of Immunology (renamed as Dept. of Pathology & Immunology since 2009), Baylor College of Medicine, Houston, Texas USA
  • 2013-present    Professor (joint appointment), Institute of Biotechnology, National Tsing-Hua University, Taiwan
  • 2007-present   Distinguished Investigator and Founding Director, Immunology Research Center; Director, Transgenic Mouse Core (since 2010), National Health Research Institutes, Taiwan

HONORS

  • 1988-1990          Postdoctoral Fellowship, Cancer Research Institute, USA
  • 1996                      Junior Faculty Research Award, American Cancer Society, USA (declined)
  • 1996-2001          Scholar Award, The Leukemia and Lymphoma Society (formerly Leukemin Society of America), USA
  • 2001-2002         Regular Member, Pathology C (PTHC) Study Section, NIH, USA
  • 2002-2006         Charter Member, Cancer Molecular Pathobiology (CAMP) Study Section, NIH, USA
  • 2009- present  Editor, American Journal of Translational Research, USA
  • 2010-2013          Councilor, Society of Chinese Bioscientists in America (SCBA)
  • 2011- present    Editor, Journal of Cell & Bioscience, USA
  • 2012                      The 22th Wang Min-Ning Memorial Award for Outstanding Contribution to the Medical Science and Technology Development, National Health, and Society, Taiwan (第22屆王民寧獎之「學術研究成果對醫藥科技發展、國民健康和國家社會傑出貢獻獎」)
  • 2014                      TBF Chair in Biotechnology, Taiwan Bio-Development Foundation (TBF) , Taiwan (台灣生技醫藥發展基金會學術講座-第一屆「TBF 生技講座」)
  • 2016-present    Associate Editor, Journal of Biomedical Science, Taiwan
  • 2016                      2016 Hou Jindui Distinguished Honor Award (侯金堆傑出榮譽獎:基礎科學生物類)
  • 2016                      2016 Outstanding Research Award, Ministry of Science and Technology, R.O.C. (科技部105年度傑出研究獎)

SELECTED PUBLICATIONS (from more than 120 peer-reviewed papers)

  1. T.‑H. Tan, J. Wallis, and A.J. Levine. 1986. Identifica­tion of the p53 protein domain involved in formation of the simian virus 40 large T‑antigen‑p53 protein complex. J. Virol.59:574‑583.  [ Abstract ]
  2. Finlay, C.A., P.W. Hinds, T.-H. Tan, D. Eliyahu, M. Oren, and A.J. Levine 1988. Activating mutations for transformat­i­on by p53 produce a gene product that forms an hsc70‑p53 complex with an altered half‑life. Mol. Cell. Biol.8:531‑539. [ Abstract ]
  3. Ruben, S., H. Poteat, T.-H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C.A. Rosen. 1988. Cellular transcription factors and regulation of IL‑2 receptor gene expression by HTLV‑I taxgene product. Science 241:89‑92. [ Abstract ]
  4. Tan, T.‑H., M. Horikoshi, and R.G. Roeder 1989. Purifica­tion and characterization of multiple nuclear factors that bind to the TAX‑inducible enhancer within the human T‑cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol.9:1733‑1745. [ Abstract ]
  5. Tan, T.‑H., R. Jia, and R.G. Roeder 1989. Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activat­or taxJ. Virol.63:3761-3768.  [ Abstract ]
  6. Tan, T.-H., G.P. Huang, A. Sica, P. Ghosh, H.A. Young, D.L. Longo, and N.R. Rice. 1992. kB site-dependent activation of the interleukin-2 receptor k-chain gene promoter by human c-Rel. Mol. Cell. Biol.12:4067-4075. [ Abstract ]
  7. Lai, J.-H., and T.-H. Tan. 1994. CD28 signaling causes a sustained down-regulation of IkB which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem.269:30077-30080. [ Abstract ]
  8. Bryan, R.G., Y. Li, J.-H. Lai, M. Van, N.R. Rice, R.R. Rich, and T.-H. Tan. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol.14:7933-7942. [ Abstract]
  9. Lai, J.-H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.-H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.Mol. Cell. Biol. 15:4260-4271. [ Abstract ]
  10. Chen, Y.-R., C.F. Meyer, and T.-H. Tan. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in g radiation-induced apoptosis. J. Biol. Chem.271:631-634. [ Abstract ]
  11. Meyer, C.F., X. Wang, C. Chang, D. Templeton, and T.-H. Tan. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kB enhancer activation. J. Biol. Chem.271:8971-8976. [ Abstract ]
  12. Hu, M.C.-T., W. Qiu, X. Wang, C.F. Meyer, and T.-H. Tan. 1996. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes & Development10:2251-2264. [ Abstract ]
  13. Wang, X.S., K. Diener, D. Jannuzzi, D. Trollinger, T.-H. Tan, H. Lichenstein, M. Zukowski, and Z. Yao. 1996. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem.271:31607-31611. [ Abstract ]
  14. Chen, Y.-R., X. Wang, D. Templeton, R.J. Davis, and T.-H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and g radiation: duration of JNK activation may determine cell death and proliferation. J. Biol. Chem.271:31929-31936. [ Abstract ]
  15. Diener, K., X.S. Wang, C. Chen, C.F. Meyer, G. Keesler, M. Zukowski, T.-H. Tan, and Z. Yao. 1997. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. USA94:9687-9692. [ Abstract ]
  16. Wang, W., G. Zhou, M.C.-T. Hu, Z. Yao, and T.-H. Tan. 1997. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor b (TGF-b)-activated kinase (TAK1), a kinase mediator of TGF-b signal transduction. J. Biol. Chem.272:22771-22775. [ Abstract ]
  17. Yao, Z., K. Diener, X.S. Wang, M. Zukowski, G. Matsumoto, G. Zhou, R. Mo, T. Sasaki, H. Nishina, C.C. Hui, T.-H. Tan, J.P. Woodgett, and J.M. Penninger. 1997. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7). J. Biol. Chem.272:32378-32383. [ Abstract ]
  18. Chen, Y.-R., W. Wang, A.-N.T. Kong, and T.-H. Tan. 1998. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem.273:1769-1775. [ Abstract ]
  19. Chen, Y.-R., and T.-H. Tan. 1998. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene17:173-178. [ Abstract ]
  20. Hu, M. C.-T., Q. Tang-Oxley, W.R. Qiu, Y.-P. Wang, K. A. Mihindukulasuriya, R. Afshar, and T.-H. Tan. 1998. Protein phosphatase X interacts with c-Rel and stimulates c-Rel/NF-kB activity. J. Biol. Chem.273:33561-33565. [ Abstract ]
  21. Yao, Z., G. Zhou, X.S. Wang, A. Brown, K. Diener, H. Gan, and T.-H. Tan. 1999. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem.274:2118-2125. [ Abstract ]
  22. Ling, P., Z. Yao, C.F. Meyer, X.S. Wang, W. Oehl, S.M. Feller, and T.-H. Tan. 1999. Interaction of HPK1 with the adaptor proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase (JNK). Mol. Cell. Biol.19:1359-1368. [ Abstract ]
  23. Hu, M.C.-T., Y.-p. Wang, A. Mikhail, W.R. Qiu, and T.-H. Tan. 1999. Murine p38-d mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J. Biol. Chem.274:7095-7102. [ Abstract ]
  24. Zhou, G., S.C. Lee, Z. Yao, and T.-H. Tan. 1999. Hematopoietic progenitor kinase 1 is a component of transforming growth factor b-induced c-Jun N-terminal kinase signaling cascade. J. Biol. Chem.274:13133-13138. [ Abstract ]
  25. Wouten, M.W., M.L. Seibenhener, G. Zhou, M.L. Vandenplas, and T.-H. Tan. 1999. Overexpression of atypical PKC in PC12 cells enhances NGF responsiveness and survival through an NF-kB pathway. Cell Death Differ.6:753-764. [ Abstract ]
  26. Hu, M.C.-T., Y.-p. Wang, W.R. Qiu, A. Mikhail, C.F. Meyer, and T.-H. Tan. 1999. Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkB kinases (IKK-a/b) and IKK-b is a developmentally regulated protein kinase. Oncogene18:5514-5524. [ Abstract]
  27. Ensenat, D., Z. Yao, X.S. Wang, R. Kori, S.C. Lee, andT.-H. Tan. 1999. A novel SH3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1 (HPK1). J. Biol. Chem. 274:33945-33950. [ Abstract ]
  28. Chen, Y.-R., G. Zhou, and T.-H. Tan. 1999. c-Jun N-terminal kinase (JNK) mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. Mol. Pharmacol.56:1271-1279. [ Abstract ]
  29. Chen, Y.-R., C.F. Meyer, B. Ahmed, Z. Yao, and T.-H. Tan.1999. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Oncogene18:7370-7377. [ Abstract]
  30. Chen, Y.-R., and T.-H. Tan. 2000. The c-Jun N-terminal kinase pathway and apoptotic signaling. Int. J. Oncology16:651-662. (Review)  [ Abstract]
  31. Chen, Y.-R., A. Shrivastava, and T.-H. Tan. 2001. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate (PDTC). Oncogene20:367-374. [ Abstract]
  32. Ling, P., C.F. Meyer, L.P. Redmond, J.-W. Shui, B. Davis, R.R. Rich, M.C.-T. Hu, R.L. Wange, and T.-H. Tan. 2001. Involvement of hematopoietic progenitor kinase 1 in T-cell receptor signaling. J. Biol. Chem.276:18908-18914. [ Abstract]
  33. Zhou, G., K.A. Mihindukulasuria, R.A. MacCorkle-Chosnek, A. Van Hooser, M. C.-T. Hu, B.R. Brinkley, and T.-H. Tan. 2002. Protein phosphatase 4 is involved in tumor necrosis factor-a-induced activation of c-Jun N-terminal kinase. J. Biol. Chem.277:6391-6398. [ Abstract ]
  34. Chen, A.J., G. Zhou, T. Juan, S.M. Colicos, J.P. Cannon, M. Cabriera-Hansen, C.F. Meyer, R. Jurecic, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, F. Fletcher, T.-H. Tan*, and J.W. Belmont*. 2002. The dual-specificity phosphatase JKAP specifically activates the c-Jun N-terminal kinase pathway. J. Biol. Chem.277:36592-36601. [ Abstract ]
  35. Chen, Y.-R., J. Han, R. Kori, A.-N.T. Kong, and T.-H. Tan. 2002. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem. 277:39334-39342. [ Abstract]
  36. Han, J., R. Kori, J.-W. Shui, Y.-R. Chen, Z. Yao, and T.-H. Tan. 2003. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase (JNK) activation in T cell receptor signaling. J. Biol. Chem.278:52196-52202. [ Abstract ]
  37. MacCorkle, R.A. and T.-H. Tan. 2004. Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. J. Biol. Chem.279:40112-40121. [ Abstract ]
  38. Shui, J.-W., and T.-H. Tan. 2004. Germline transmission and efficient DNA recombination in mouse embryonic stem cells mediated by adenoviral-Cre transduction. Genesis39:217-223. [ Abstract ]
  39. Mihindukulasuriya, K.A., G. Zhou, J. Qin, and T.-H. Tan. 2004. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-a stimulation. J. Biol. Chem.279:46588-46594. [ Abstract ]
  40. 40 Zhou, G., J.S. Boomer, and T.-H. Tan. 2004. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. J. Biol. Chem. 279:49551-49561. [ Abstract ]
  1. Zhang, X., Y. Ozawa, H. Lee, Y.-D. Wen, T.-H. Tan, B.E. Wadzinski, and E. Seto. 2005. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev.19:827-839. [ Abstract ]
  2. Boomer, J.S., and T.-H. Tan.2005. Functional interaction of HPK1 with adaptor proteins. J. Cell. Biochem. 95:34-44. (Review) [ Abstract ]
  3. Han, J., J.-W. Shui, X. Zhang, B. Zheng, S. Han, and T.-H. Tan.2005. HIP-55 is important for T-cell proliferation, cytokine production and immune responses. Mol. Cell. Biol. 25:6869-6878. [ Abstract ]
  4. MacCorkle, R.A. and T.-H. Tan.2005. Mitogen-activated protein kinases in cell-cycle control. Cell Biochem. Biophy. 43:451-462. (Review) [ Abstract ]
  5. Wang, J.-Y., C.-H. Lin, C.-H. Yang, T.-H. Tan, and Y.-R. Chen. 2006. Biological and biochemical characterization of a neuroendocrine-associated phosphatase (NEAP). J. Neurochem.98:89-101. [ Abstract ]
  6. Shui, J.-W., M.C.-T. Hu, and T.-H. Tan.2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell-receptor signaling. Mol. Cell. Biol. 27:79-91. [ Abstract ]
  7. Shui, J.-W., J.S. Boomer, J. Han, J. Xu, G.A. Dement, G. Zhou, and T.-H. Tan. 2007. HPK1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.Nature Immunol.8:84-91. [ Abstract ]

Highlighted in Nature Signaling Gateway, Signaling Update “T Cell Signaling: Giving HPK1 the SLP”, 2007 January.

  1. Liang, J.J., H. Wang, A. Rashid, T.-H. Tan, R.F. Hwang, S.R. Hamilton, J.L. Abbruzzese, and D.B. Evans. 2008. Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin. Cancer Res.14:7043-7049. [ Abstract ]
  2. Onabajo, O.O., M.K. Seeley, A. Kale, B. Qualmann, M. Kessels, J. Han, T.-H. Tan, and W. Song. 2008. Actin binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J. Immunol.180:6685-6695. [ Abstract ]
  3. Wang, H., X. Song, C. Logsdon, G. Zhou, D.B. Evans, J.L. Abbruzzese, S.R. Hamilton, T.-H. Tan, and H. Wang. 2009. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Cancer Res.69:1063-1070. [ Abstract ]
  4. Tucker, K.L., W.J. Kaiser, A.L. Bergeron, H. Hu, J.F. Dong, T.-H. Tan, and J.M. Gibbins. 2009. Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics9:4340-4354. [ Abstract ]
  5. Li, J.P., Y.N. Fu, Y.R. Chen, and T.-H. Tan. 2010. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285:5472-5478. [ Abstract]
  6. Chuang, H.C., J.L. Lan, D.Y. Chen, C.Y. Yang, Y.M. Chen, J.P. Li, C.Y. Huang, P.E. Liu, X. Wang, and T.-H. Tan. 2011. The kinase GLK controls autoimmunity and NF-kB signaling by activating the kinase PKC-θ in T cells . Nature Immunol.12:1113-1118. [ Abstract ]

Highlighted in News & Views of Nature Immunol. 12:1031-1032. [ link ]

Highlighted in Science-Business eXchange (SciBX). 4:42 Oct. 27, 2011

Highlighted in A-IMBN Research on 27 Dec. 27, 2011. [ link ]

  1. Wang, X., J.-P. Li, H.-K. Kuo, L.-L. Chiu, G.A. Dement, J.-L. Lan, D.-Y. Chen, C.-Y. Yang, H. Hu, and T.-H. Tan. 2012. Downregulation of B-cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of the activated BLNK.J. Biol. Chem. 287: 11037-11048. [ Abstract ]
  2. Huang, C.-Y.*, Y.-C. Lin, W.-Y. Hsiao, F.-S. Liao, P.-Y. Huang, and T.-H. Tan*. 2012. DUSP4 deficiency enhances CD25 expression and CD4 T-cell proliferation without impeding T-cell development. Eur. J. Immunol.42:476-488. [ Abstract]
  3. Wang X, Chuang HC, Li JP, T.-H. Tan. 2012. Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol.2012 Jul 11;3:197. doi: 10.3389/fimmu.2012.00197.[ Abstract ]
  4. Huang, C.Y. and T.-H. Tan. 2012. DUSPs, to MAP kinases and beyond. Cell & Biosci.2:24. [ Abstract]
  5. Chen, D.Y., H.C. Chuang, J.L. Lan, Y.M. Chen, W.T. Hung, K.L. Lai and T.-H. Tan. 2012. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still’s disease and may act as an activity marker. BMC Med.10:84. [ Abstract ]
  6. Chen, K.R., C.H. Chang, C.Y.  Huang, C.Y. Lin, W.Y. Lin, Y.C. Lo, C.Y. Yang, E.W. Hsing, L.F. Chen, S.R. Shih, A.L. Shiau, H.Y. Lei, T.-H. Tan, and P. Ling. 2012. TBK1-associated Protein in Endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J. Biol. Chem.287:32216-32221. [ Abstract ]
  7. Wang, X.H., J.P. Li, L.L. Chiu, J.L. Lan, D.Y. Chen, J. Boomer, and T.-H. Tan.2012. Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J. Biol. Chem.287:34091-34100. [ Abstract ]
  8. Chen, Y.-M., Chuang, H.-C., Lin, W.-C., Tsai, C.-Y., Wu, C.-W., Gong, N.-R., Hung, W.-T., Lan, T.-H., Lan, J.-L., Tan, T.-H., Chen, D.-Y. 2013. Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis.Arthritis Rheum. 65:2573-2582.
    [ Supplementary files] [ Abstract ]
  9. Su YW, Chen YP, Chen MY, Reth M, and  Tan, T.-H. 2013. The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of Ig VDJ recombination. PLoS One. 8:e68804. [ Abstract ]
  10. Zhou G, Wang H, Liu SH, Shahi KM, Lin X, Wu J, Feng XH, Qin J, Tan, T.-H., Brunicardi FC. 2013. p38 MAP kinase interacts with and stabilizes pancreatic and duodenal homeobox-1.Curr. Mol. Med.13:377-386.[ Abstract ]
  11. Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan, T.-H., Wang H. 2014. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor Kinase 1.J. Biol.  Chem.289:4009-4017. [ Abstract ]
  12. Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan, T.-H. 2014. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.J. Immunol. 192:1547-1557. [ Abstract ]
  13. Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan, T.-H.2014. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.Nature Communications. 5:3618. [ Abstract ]
  14. Liao FH, Shui JW, Hsing EW, Hsiao WY, Lin YC, Chan YC, Tan, T.-H.* and Huang CY*. 2014. Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity. Cell Biosci. 4:25.[Abstract ]
  15. Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan, T.-H, Upadhyaya A, Song W. 2014. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci USA.111:9881-9886.[ Abstract ]
  16. Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan, T.-H. 2014. HGK/​MAP4K4 deficiency induces ​TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications.5:4602.[ Abstract ]
  17. MY Chen, YP Chen, MS Wu, GY Yu, WJ Lin, Tan, T.-H.and Yu-Wen Su*. 2014. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 12:e107505.[ Abstract ]
  18. Chuang HC, Wang X, Tan T.-H.2016. MAP4K family kinases in immunity and inflammation. Advances in Immunology.129:277-314 [ Abstract ]
  19. CY Yang, LL Chiu,Tan, T.-H. 2016. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cellular Signalling. 28:145-151.[Abstract ]
  20. HC Chuang, JS Wang, IT Lee, W H-H. Sheu* and Tan, T.-H*. 2016. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 7:10976-10989.[Abstract ]
  21. Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan, T.-H*. 2016. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget. 7:41748-41757.[Abstract ]
  22. Ho CH, Chuang HC, Wu IC, Tsai HW, Lin YJ, Sun HY, Young KC, Chiu YC, Cheng PN, Liu WC, Tan, T.-H* and Chang TT* 2016. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget. 7:49765-49776.[Abstract ]
  23. Chuang, H.C, Y. M Chen, W.T. Hung, J.P. Li, D.Y. Chen*, J.L. Lan* and Tan, T.-H*. 2016. Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget7:57593-57605.[Abstract ]
  24. Ruan JW, Statt S, Huang CT, Tsai YT, Kuo CC, Chan HL, Liao YC, Tan TH, Kao CY*. 2016. Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice.Nature Microbiology.2:16220.[ Abstract ]
  25. Chuang, HC and T.-H. Tan*.2017. MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. Journal of Biomedical Science. (Invited review) 24:4.[ Abstract ]
  26. YR Chen, HC Chou, CH Yang, HY Chen, YW Liu, TY Lin, CL Yeh, WT Chao, HH Tsou, HC Chuang and T.-H. Tan*.2017. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 36:6509-6517[ Abstract ]
  27. JC Lin, YC Lee, T.-H. Tan, YC Liang, HC Chuang, YC Fann, Kory R. Johnson, YJ Lin*. 2018. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell. Biochim Biophys Acta Mol Cell Res. 1865:259-272.[ Abstract ]
  28. Chuang, HC and T.-H. Tan*.2018. MAP4K3 (GLK). Encyclopedia of Signaling Molecules. (Book-chapter) Pages: 1-5. [ Abstract ]
  29. Yang CY, LL Chiu, CC Chang, HC Chuang*, and T.-H. Tan*. 2018. Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation in T-cell signaling. FASEB Journal. 2018.  32:6760-6770. [Epub ahead of print] [Abstract]
  30. Hsu WC, MY Chen, SC Hsu, LR Huang, WH Cheng, MS Hung, MS Wu, GY Yu, CM Leu, T.-H. Tan and YW Su*. 2018. DUSP6 connects T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci USA. 115: E8027-E8036.  [ Abstract ]
  31. Peng HY, YC Liang, T.-H. Tan, HC Chuang, YJ Lin and JC Lin. 2018. RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. Int J Mol Sci. 2018. 19: 2646; doi: 10.3390/ijms19092646 [ Abstract]
  32. Chuang HC, CY Tsai, CH Hsueh and T.-H. Tan*. 2018. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Science Advances. 2018; 4: eaat5401. [ Abstract]
  33. Chen MY, WC Hsu, SC Hsu, YS Yang, TH Chuang, WJ Lin, T.-H. Tan and YW Su. 2019. PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency. Cell Death & Differentiation. 2019. 26:1221-1234.  [ Abstract]
  34. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M1 Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W1, Habib J, Narasimham P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, T.-H. Tan, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 24:579-591. [ Abstract ]
  35. Chen HF, HC Chuang* and T.-H. Tan *. 2019. Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability. International Journal of Molecular Sciences. 20:2668. [ Abstract ]
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