蘇郁文副研究員

Yu-wen Su                                                                                                Profile updated: Oct 17, 2018

Associate Investigator                                                                                  ResearcherID: E-8804-2010

Immunology Research Center, National Health Research Institutes


[Contact Information]

Phone     +886-37-206166 Ext. 37619 / 37621

Fax           +886-37-586642

Email       yuwensu@nhri.edu.tw

Address  35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)


Research Interest and Specialty

B and T-lineage lymphopoiesis; Immune regulation and immune response; Tumorigenesis and lymphoma; Cell signaling

Educations and Positions

  • 1990-1994   Bachelor degree of Science
    National Yang-Ming Medical University, Department of Medical Technology, Taipei, Taiwan
  • 1995-1999   Diplom Biologist
    Institute for Biology III, Albert Ludwig University of Freiburg, Germany
    Max-Planck Institute for Immunobiology, Department of Molecular Immunology, Freiburg, Germany
    Laboratory M. Reth and J. Wienands
  • 1999-2004   Ph.D. of Philosophy
    Institute for Biology III, Albert Ludwig University of Freiburg, Germany
    Max-Planck Institute for Immunobiology, Department of Molecular Immunology, Freiburg, Germany
    Laboratory M. Reth and H. Jumaa
  • 2004-2010   Postdoctoral fellow
    Laboratory Tak W. Mak, Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, University Health Network, Toronto, Canada
  • 2010 March-  Assistant Investigator
    Immunology Research Center, National Health Research Institutes

Honors

  • 2007 Jan-2009 Dec    Post doc. fellowship award from Cancer Research Institute, New York, USA, with the title” The Role of 14-3-3sigma in Immune Development and Lymphoid Tumorigenesis”

Publications

  1. Yu-wen Su, Yong Zhang, Jutta Schweikert, Gary Koretzky, Michael Reth and Juergen Wienands. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur. J. Immunol. 1999. 29: 3702-3711 [ Abstract]
  2. Yu-wen Suand Hassan Jumaa. LAT links the Pre-BCR to Calcium Signaling. Immunity, Vol.19, 295-305, August, 2003 [ Abstract ]
  3. Yu-wen Su, Alexandra Flemming, Thomas Wossning, Elias Hobeika, Michael Reth and Hassan Jumaa. Identification of a Pre-BCR Lacking Surrogate Light Chain.J. Exp. Med, Vol 198, 1699-1707, December, 2003 [ Abstract ]
  4. Yu-wen Su, Sebastian Herzog, Michael Lotz, Niklas Feldhahn, Markus Mueschen and Hassan Jumaa. The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion. Eur. J. Immunol.2004. 34: 3614-3622 [ Abstract ]
  5. Kathrin Zaugg, Yu-wen Su, Patrick Reilly, Yasmin Moolani, Carol Cheung, Razquallah Hakem, Atsushi Hirao, Quinghua Liu, Stephen Elledge and Tak Mak. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A.2007. 104(10): 3805-10. [ Abstract ]
  6. Nien-Jung Chen, Iok In Christine Chio, Wen-Jye Lin, Gordon Duncan, Hien Chau, David Katz, Huey-Lan Huang, Kelly A. Pike, Zhenyue Hao, Yu-Wen Su, Kazuo Yamamoto, Renée F. de Pooter, Juan Carlos Zúñiga-Pflücker, Andrew Wakeham, Wen-Chen Yeh and Tak W. Mak. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A.2008. 105(34):12429-34. [ Abstract ]
  7. Zhenyue Hao, Gordon S. Duncan, Jane Seagal, Yu-Wen Su, Claire Hong1, Jillian Haight, Nien-Jung Chen, Andrew Elia, Andrew Wakeham, Wanda Y. Li, Jennifer Liepa, Geoffrey A. Wood, Stefano Casola, Klaus Rajewsky, and Tak W. Mak. Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis. Immunity.2008. 29 (4): 615-627. [ Abstract ]
  8. Yu-Wen Su, Zhenyue Hao, Atsushi Hirao, Kazuo Yamamoto, Wen-Jye Lin, Ashley Young, Gordon S. Duncan, Hiroki Yoshida, Andrew Wakeham, Philipp A. Lang,Kiichi Murakami, Heiko Hermeking, Bert Vogelstein, Pamela Ohashi, and Tak W. Mak. 14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proc Natl Acad Sci U S A. 2011. 108 (4):1555-60. [ Abstract ]
  9. Wen-Jye Lin, Yu-Wen Su, Yong-Chen Lu, Zhenyue Hao, Iok In Christine Chio, Nien-Jung Chen, Anne Brüstle, Wanda Y. Li and Tak W. Mak. Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity. Proc Natl Acad Sci U S A. 2011. 108 (45):18354-9. [ Abstract ]
  10. Yu-wen Su*, Ya-ping Chen, Ming-yu Chen, Michael Reth and Tse-Hua Tan The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination . PLON ONE. 2013. (*corresponding author) [ Abstract ]
  11. Wei-Chan Hsu, Ming-Yu Chen, Shu-Ching Hsu, Li-Rung Huang, Cheng-Yuan Kao, Wen-Hui Cheng, Chien-Hsiung Pan, Ming-Sian Wu, Guann-Yi Yu, Ming-Shiu Hung, Chuen-Miin Leu, Tse-Hua Tan and Yu-Wen Su*. 2018 DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci U S A 2018. 115:E8027-E8036. (*corresponding author) [ Abstract ]
  12. Ming-Yu Chen, Wei-Chan Hsu, Shu-Ching Hsu, Yu-Shao Yang, Tsung-Hsien Chuang, Wei-Jye Lin, Tse-Hua Tan and Yu-Wen Su* PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency. Cell Death & Differentiation. 2018. Epub on Sep. 21. (*corresponding author). [ Abstract ]
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