Additional Selected Publications List

    Tse-Hua Tan Distinguished Investigator   (Publications updated: August 2, 2022)

  1. T.‑H. Tan, J. Wallis, and A.J. Levine. 1986. Identifica­tion of the p53 protein domain involved in formation of the simian virus 40 large T‑antigen‑p53 protein complex. J. Virol. 59:574‑583.  [ Abstract ]
  2. Finlay, C.A., P.W. Hinds, T.-H. Tan, D. Eliyahu, M. Oren, and A.J. Levine 1988. Activating mutations for transformat­i­on by p53 produce a gene product that forms an hsc70‑p53 complex with an altered half‑life. Mol. Cell. Biol. 8:531‑539. [ Abstract ]
  3. Ruben, S., H. Poteat, T.-H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C.A. Rosen. 1988. Cellular transcription factors and regulation of IL‑2 receptor gene expression by HTLV‑I tax gene product. Science. 241:89‑92. [ Abstract ]
  4. Tan, T.‑H., M. Horikoshi, and R.G. Roeder 1989. Purifica­tion and characterization of multiple nuclear factors that bind to the TAX‑inducible enhancer within the human T‑cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 9:1733‑1745. [ Abstract ]
  5. Tan, T.‑H., R. Jia, and R.G. Roeder 1989. Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activat­or taxJ. Virol. 63:3761-3768.  [ Abstract ]
  6. Tan, T.-H., G.P. Huang, A. Sica, P. Ghosh, H.A. Young, D.L. Longo, and N.R. Rice. 1992. kB site-dependent activation of the interleukin-2 receptor k-chain gene promoter by human c-Rel. Mol. Cell. Biol. 12:4067-4075. [ Abstract ]
  7. Lai, J.-H., and T.-H. Tan. 1994. CD28 signaling causes a sustained down-regulation of IkB which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem. 269:30077-30080. [ Abstract ]
  8. Bryan, R.G., Y. Li, J.-H. Lai, M. Van, N.R. Rice, R.R. Rich, and T.-H. Tan. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933-7942. [ Abstract]
  9. Lai, J.-H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.-H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260-4271. [ Abstract ]
  10. Chen, Y.-R., C.F. Meyer, and T.-H. Tan. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in ɣ radiation-induced apoptosis. J. Biol. Chem. 271:631-634. [ Abstract ]
  11. Meyer, C.F., X. Wang, C. Chang, D. Templeton, and T.-H. Tan. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kB enhancer activation. J. Biol. Chem. 271:8971-8976. [ Abstract ]
  12. Hu, M.C.-T., W. Qiu, X. Wang, C.F. Meyer, and T.-H. Tan. 1996. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes & Development. 10:2251-2264. [ Abstract ]
  13. Wang, X.S., K. Diener, D. Jannuzzi, D. Trollinger, T.-H. Tan, H. Lichenstein, M. Zukowski, and Z. Yao. 1996. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem. 271:31607-31611. [ Abstract ]
  14. Chen, Y.-R., X. Wang, D. Templeton, R.J. Davis, and T.-H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and ɣ radiation: duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936. [ Abstract ]
  15. Diener, K., X.S. Wang, C. Chen, C.F. Meyer, G. Keesler, M. Zukowski, T.-H. Tan, and Z. Yao. 1997. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. USA. 94:9687-9692. [ Abstract ]
  16. Wang, W., G. Zhou, M.C.-T. Hu, Z. Yao, and T.-H. Tan. 1997. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor β (TGF-β)-activated kinase (TAK1), a kinase mediator of TGF-β signal transduction. J. Biol. Chem. 272:22771-22775. [ Abstract ]
  17. Yao, Z., K. Diener, X.S. Wang, M. Zukowski, G. Matsumoto, G. Zhou, R. Mo, T. Sasaki, H. Nishina, C.C. Hui, T.-H. Tan, J.P. Woodgett, and J.M. Penninger. 1997. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7). J. Biol. Chem. 272:32378-32383. [ Abstract ]
  18. Chen, Y.-R., W. Wang, A.-N.T. Kong, and T.-H. Tan. 1998. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem. 273:1769-1775. [ Abstract ]
  19. Chen, Y.-R., and T.-H. Tan. 1998. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene17:173-178. [ Abstract ]
  20. Hu, M. C.-T., Q. Tang-Oxley, W.R. Qiu, Y.-P. Wang, K. A. Mihindukulasuriya, R. Afshar, and T.-H. Tan. 1998. Protein phosphatase X interacts with c-Rel and stimulates c-Rel/NF-kB activity. J. Biol. Chem. 273:33561-33565. [ Abstract ]
  21. Yao, Z., G. Zhou, X.S. Wang, A. Brown, K. Diener, H. Gan, and T.-H. Tan. 1999. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem. 274:2118-2125. [ Abstract ]
  22. Ling, P., Z. Yao, C.F. Meyer, X.S. Wang, W. Oehl, S.M. Feller, and T.-H. Tan. 1999. Interaction of HPK1 with the adaptor proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase (JNK). Mol. Cell. Biol. 19:1359-1368. [ Abstract ]
  23. Hu, M.C.-T., Y.-p. Wang, A. Mikhail, W.R. Qiu, and T.-H. Tan. 1999. Murine p38-δ mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J. Biol. Chem. 274:7095-7102. [ Abstract ]
  24. Zhou, G., S.C. Lee, Z. Yao, and T.-H. Tan. 1999. Hematopoietic progenitor kinase 1 is a component of transforming growth factor β-induced c-Jun N-terminal kinase signaling cascade. J. Biol. Chem. 274:13133-13138. [ Abstract ]
  25. Wouten, M.W., M.L. Seibenhener, G. Zhou, M.L. Vandenplas, and T.-H. Tan. 1999. Overexpression of atypical PKC in PC12 cells enhances NGF responsiveness and survival through an NF-kB pathway. Cell Death Differ. 6:753-764. [ Abstract ]
  26. Hu, M.C.-T., Y.-p. Wang, W.R. Qiu, A. Mikhail, C.F. Meyer, and T.-H. Tan. 1999. Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkB kinases (IKK-α/β) and IKK-β is a developmentally regulated protein kinase. Oncogene. 18:5514-5524. [ Abstract]
  27. Ensenat, D., Z. Yao, X.S. Wang, R. Kori, S.C. Lee, and T.-H. Tan. 1999. A novel SH3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1 (HPK1). J. Biol. Chem. 274:33945-33950. [ Abstract ]
  28. Chen, Y.-R., G. Zhou, and T.-H. Tan. 1999. c-Jun N-terminal kinase (JNK) mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. Mol. Pharmacol. 56:1271-1279. [ Abstract ]
  29. Chen, Y.-R., C.F. Meyer, B. Ahmed, Z. Yao, and T.-H. Tan. 1999. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Oncogene. 18:7370-7377. [ Abstract]
  30. Chen, Y.-R., and T.-H. Tan. 2000. The c-Jun N-terminal kinase pathway and apoptotic signaling. Int. J. Oncology. 16:651-662. (Review)  [ Abstract]
  31. Chen, Y.-R., A. Shrivastava, and T.-H. Tan. 2001. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate (PDTC). Oncogene. 20:367-374. [ Abstract]
  32. Ling, P., C.F. Meyer, L.P. Redmond, J.-W. Shui, B. Davis, R.R. Rich, M.C.-T. Hu, R.L. Wange, and T.-H. Tan. 2001. Involvement of hematopoietic progenitor kinase 1 in T-cell receptor signaling. J. Biol. Chem. 276:18908-18914. [ Abstract]
  33. Zhou, G., K.A. Mihindukulasuria, R.A. MacCorkle-Chosnek, A. Van Hooser, M. C.-T. Hu, B.R. Brinkley, and T.-H. Tan. 2002. Protein phosphatase 4 is involved in tumor necrosis factor-α-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 277:6391-6398. [ Abstract ]
  34. Chen, A.J., G. Zhou, T. Juan, S.M. Colicos, J.P. Cannon, M. Cabriera-Hansen, C.F. Meyer, R. Jurecic, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, F. Fletcher, T.-H. Tan*, and J.W. Belmont*. 2002. The dual-specificity phosphatase JKAP specifically activates the c-Jun N-terminal kinase pathway. J. Biol. Chem. 277:36592-36601. [ Abstract ]
  35. Chen, Y.-R., J. Han, R. Kori, A.-N.T. Kong, and T.-H. Tan. 2002. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem. 277:39334-39342. [ Abstract]
  36. Han, J., R. Kori, J.-W. Shui, Y.-R. Chen, Z. Yao, and T.-H. Tan. 2003. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase (JNK) activation in T cell receptor signaling. J. Biol. Chem. 278:52196-2202. [ Abstract ]
  37. MacCorkle, R.A. and T.-H. Tan. 2004. Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. J. Biol. Chem. 279:40112-40121. [ Abstract ]
  38. Shui, J.-W., and T.-H. Tan. 2004. Germline transmission and efficient DNA recombination in mouse embryonic stem cells mediated by adenoviral-Cre transduction. Genesis. 39:217-223. [ Abstract ]
  39. Mihindukulasuriya, K.A., G. Zhou, J. Qin, and T.-H. Tan. 2004. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-α stimulation. J. Biol. Chem. 279:46588-46594. [ Abstract ]
  40.  Zhou, G., J.S. Boomer, and T.-H. Tan. 2004. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. J. Biol. Chem. 279:49551-49561. [ Abstract ]

  1. Zhang, X., Y. Ozawa, H. Lee, Y.-D. Wen, T.-H. Tan, B.E. Wadzinski, and E. Seto. 2005. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes & Development. 19:827-839. [ Abstract ]
  2. Boomer, J.S., and T.-H. Tan. 2005. Functional interaction of HPK1 with adaptor proteins. J. Cell. Biochem. 95:34-44. (Review) [ Abstract ]
  3. Han, J., J.-W. Shui, X. Zhang, B. Zheng, S. Han, and T.-H. Tan. 2005. HIP-55 is important for T-cell proliferation, cytokine production and immune responses. Mol. Cell. Biol. 25:6869-6878. [ Abstract ]
  4. MacCorkle, R.A. and T.-H. Tan. 2005. Mitogen-activated protein kinases in cell-cycle control. Cell Biochem. Biophy. 43:451-462. (Review) [ Abstract ]
  5. Wang, J.-Y., C.-H. Lin, C.-H. Yang, T.-H. Tan, and Y.-R. Chen. 2006. Biological and biochemical characterization of a neuroendocrine-associated phosphatase (NEAP). J. Neurochem. 98:89-101. [ Abstract ]
  6. Shui, J.-W., M.C.-T. Hu, and T.-H. Tan. 2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell-receptor signaling. Mol. Cell. Biol. 27:79-91. [ Abstract ]
  7. Shui, J.-W., J.S. Boomer, J. Han, J. Xu, G.A. Dement, G. Zhou, and T.-H. Tan. 2007. HPK1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nature Immunology. 8:84-91. [ Abstract ]   Highlighted in Nature Signaling Gateway, Signaling Update “T Cell Signaling: Giving HPK1 the SLP”,  2007 January.               
  8. Liang, J.J., H. Wang, A. Rashid, T.-H. Tan, R.F. Hwang, S.R. Hamilton, J.L. Abbruzzese, and D.B. Evans. 2008. Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin. Cancer Res. 14:7043-7049. [ Abstract ]
  9. Onabajo, O.O., M.K. Seeley, A. Kale, B. Qualmann, M. Kessels, J. Han, T.-H. Tan, and W. Song. 2008. Actin binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J. Immunol. 180:6685-6695. [ Abstract ]
  10. Wang, H., X. Song, C. Logsdon, G. Zhou, D.B. Evans, J.L. Abbruzzese, S.R. Hamilton, T.-H. Tan, and H. Wang. 2009. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Cancer Res. 69:1063-1070. [ Abstract ]
  11. Tucker, K.L., W.J. Kaiser, A.L. Bergeron, H. Hu, J.F. Dong, T.-H. Tan, and J.M. Gibbins. 2009. Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics. 9:4340-4354. [ Abstract ]
  12. Li, J.P., Y.N. Fu, Y.R. Chen, and T.-H. Tan. 2010. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285:5472-5478. [ Abstract]
  13. Chuang, H.C., J.L. Lan, D.Y. Chen, C.Y. Yang, Y.M. Chen, J.P. Li, C.Y. Huang, P.E. Liu, X. Wang, and T.-H. Tan. 2011. The kinase GLK controls autoimmunity and NF-kB signaling by activating the kinase PKC-θ in T cells . Nature Immunology. 12:1113-1118. [ Abstract ]

            Highlighted in News & Views of Nature Immunology. 12:1031-1032. [ link ]

            Highlighted in Science-Business eXchange (SciBX). 4:42 Oct. 27, 2011

            Highlighted in A-IMBN Research on 27 Dec. 27, 2011. [ link ]

  1. Wang, X., J.-P. Li, H.-K. Kuo, L.-L. Chiu, G.A. Dement, J.-L. Lan, D.-Y. Chen, C.-Y. Yang, H. Hu, and T.-H. Tan. 2012. Downregulation of B-cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of the activated BLNK. J. Biol. Chem. 287: 11037-11048. [ Abstract ]
  2. Huang, C.-Y., Y.-C. Lin, W.-Y. Hsiao, F.-S. Liao, P.-Y. Huang, and T.-H. Tan. 2012. DUSP4 deficiency enhances CD25 expression and CD4 T-cell proliferation without impeding T-cell development. Eur. J. Immunology. 42:476-488. [ Abstract]
  3. Wang X, Chuang HC, Li JP, T.-H. Tan. 2012. Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol. 3:197. (Review) [ Abstract ]
  4. Huang, C.Y. and T.-H. Tan. 2012. DUSPs, to MAP kinases and beyond. Cell & Biosci. 2:24. (Review)   [ Abstract]
  5. Chen, D.Y., H.C. Chuang, J.L. Lan, Y.M. Chen, W.T. Hung, K.L. Lai and T.-H. Tan. 2012. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still’s disease and may act as an activity marker. BMC Medicine10:84. [ Abstract ]
  6. Chen, K.R., C.H. Chang, C.Y.  Huang, C.Y. Lin, W.Y. Lin, Y.C. Lo, C.Y. Yang, E.W. Hsing, L.F. Chen, S.R. Shih, A.L. Shiau, H.Y. Lei, T.-H. Tan, and P. Ling. 2012. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J. Biol. Chem. 287:32216-32221.                          [ Abstract ]
  7. Wang, X.H., J.P. Li, L.L. Chiu, J.L. Lan, D.Y. Chen, J. Boomer, and T.-H. Tan. 2012. Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J. Biol. Chem. 287:34091-34100. [ Abstract ]
  8. Chen, Y.-M., H.-C. Chuang, W.-C. Lin, , C.-Y. Tsai, C.-W. Wu, N.-R. Gong, W.-T. Hung,  T.-H. Lan, J.-L. Lan, T.-H. Tan, D.-Y. Chen. 2013. Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis. Arthritis & Rheumatism. 65:2573-2582.
    [ Abstract ]
  9. Su, Y.W.,  YP Chen, MY Chen, M Reth, and T.-H. Tan. 2013. The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of Ig VDJ recombination. PLoS One. 8:e68804. [ Abstract ]
  10. Zhou, G., H. Wang, S.H. Liu, K.M. Shahi, X. Lin, J. Wu, X.H. Feng, J. Qin, T.-H. Tan, F.C. Brunicardi. 2013. p38 MAP kinase interacts with and stabilizes pancreatic and duodenal homeobox-1. Curr. Mol. Med. 13:377-386. [ Abstract ]
  11. Wang, H., Y. Chen, P. Lin, L. Li, G. Zhou, G. Liu, C. Logsdon, J. Jin, J.L. Abbruzzese, T.-H. Tan, H Wang. 2014. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor Kinase 1. J. Biol. Chem. 289:4009-4017. [ Abstract ]
  12. Yang, C.Y., J.P. Li, L.L. Chiu, J.L. Lan, D.Y. Chen, H.C. Chuang, C.Y. Huang, T.-H. Tan. 2014. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J. Immunology. 192:1547-1557. [ Abstract ]
  13. Li, J.P., C.Y. Yang, H.C Chuang, J.L. Lan, D.Y. Chen, Y.M. Chen, X. Wang, A.J. Chen, J.W. Belmont, T.-H Tan. 2014. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nature Communications. 5:3618. [ Abstract ]
  14. Liao, F.H., J.W. Shui, E.W. Hsing, W.Y. Hsiao, Y.C. Lin, Y.C. Chan, T.-H. Tan* and C.Y. Huang *. 2014. Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity. Cell Biosci. 4:25. [Abstract ]
  15. Seeley-Fallen MK, LJ Liu , MR Shapiro , OO Onabajo, S Palaniyandi, X Zhu, T.-H Tan, A Upadhyaya, W Song. 2014. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci USA. 111:9881-9886. [ Abstract ]
  16. Chuang, H.C., W.H. Sheu, Y.T. Lin, C.Y. Tsai, C.Y. Yang, Y.J. Cheng, P.Y. Huang, J.P. Li, L.L. Chiu, X. Wang, M. Xie, M.D. Schneider, and T.-H. Tan. 2014. HGK/​MAP4K4 deficiency induces ​TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications. 5:4602. [ Abstract ]
  17. MY Chen, YP Chen, MS Wu, GY Yu, WJ Lin,  T.-H. Tan and Yu-Wen Su*. 2014. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 12:e107505. [ Abstract ]
  18. Chuang HC, X Wang, and  T.-H. Tan. 2016. MAP4K family kinases in immunity and inflammation. Advances in Immunology. 129:277-314. (Review) [ Abstract ]
  19. CY Yang, LL Chiu, and T.-H. Tan. 2016. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cellular Signalling. 28:145-151[Abstract ]
  20. HC Chuang, JS Wang, IT Lee, W H-H. Sheu and Tan, T.-H. 2016. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 7:10976-10989[Abstract ]
  21. Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, T.-H. Tan. 2016. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget. 7:41748-41757[Abstract ]
  22. Ho CH, HC Chuang, IC Wu, HW Tsai, YJ Lin, HY Sun, KC Young, YC Chiu, PN Cheng, WC Liu, T.-H. Tan* and  TT Chang* 2016. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget. 7:49765-49776. [Abstract ]
  23. Chuang, H.C., Y. M. Chen, W.T. Hung, J.P. Li, D.Y. Chen, J.L. Lan and T.-H. Tan. 2016. Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget. 7:57593-57605[Abstract ]
  24. Ruan, JW, S Statt, CT Huang, YT Tsai, CC Kuo, HL Chan, YC Liao, TH Tan, CY Kao*. 2016. Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice. Nature Microbiology. 2:16220. [ Abstract ]
  25. Chuang, HC and T.-H. Tan. 2017. MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. Journal of Biomedical Science. 24:4. (Review) [ Abstract ]
  26. YR Chen, HC Chou, CH Yang, HY Chen, YW Liu, TY Lin, CL Yeh, WT Chao, HH Tsou, HC Chuang and T.-H. Tan. 2017. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 36:6509-6517[ Abstract ]
  27. JC Lin, YC Lee, T.-H. Tan, YC Liang, HC Chuang, YC Fann, Kory R. Johnson, YJ Lin. 2018. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell. Biochim Biophys Acta Mol Cell Res. 1865:259-272. [ Abstract ]
  28. Chuang, HC and T.-H. Tan. 2018. MAP4K3 (GLK). Encyclopedia of Signaling Molecules. (Book-chapter) Pages: 1-5. [ Abstract ]
  29. Yang CY, LL Chiu, CC Chang, HC Chuang, and T.-H. Tan. 2018. Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation in T-cell signaling. FASEB Journal. 2018. 32:6760-6770. [Abstract]
  30. Hsu WC, MY Chen, SC Hsu, LR Huang, WH Cheng, MS Hung, MS Wu, GY Yu, CM Leu, T.-H. Tan and YW Su. 2018. DUSP6 connects T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci USA. 115: E8027-E8036. [ Abstract ]
  31. Peng HY, YC Liang, T.-H. Tan, HC Chuang, YJ Lin and JC Lin. 2018. RBM4a-SRSF3-MAP4K4 splicing cascade constitutes a molecular mechanism for regulating brown ddipogenesis. Int J Mol Sci. 2018. 19: 2646. [ Abstract]
  32. Chuang HC, CY Tsai, CH Hsueh and T.-H. Tan. 2018. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Science Advances. 4: eaat5401. [ Abstract]
  33. Chen MY, WC Hsu, SC Hsu, YS Yang, TH Chuang, WJ Lin, T.-H. Tan and YW Su. 2019. PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency. Cell Death & Differentiation. 26:1221-1234.  [ Abstract]
  34. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M1 Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W1, Habib J, Narasimham P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, T.-H. Tan, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces Infarct size in vivo. Cell Stem Cell. 24:579-591. [ Abstract ]
  35. Chen, H.F., H.C. Chuang and T.-H. Tan. 2019. Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability. Int J Mol Sci. 20:2668. (Review) [ Abstract ]
  36. Chuang HC, CC Chang , CF Teng, CH Hsueh, LL Chiu, PM Hsu, MC Lee, CP Hsu, YR Chen, YC Liu, PC Lyu, and T.-H. Tan. MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Research. 2019. 79:4978-4993. [ Abstract ]
  37. Chuang HC, Chen YM, Chen MH, Hung WT, Yang HY, Tseng TH, and T.-H. Tan. AhR-RORγt complex is a therapeutic target for MAP4K3/GLKhighIL-17Ahigh subpopulation of systemic lupus erythematosus. FASEB Journal. 2019. 33:11469-11480. [ Abstract ]
  38. Chuang HC and T.-H. Tan. MAP4K3/GLK in autoimmune disease, cancer and aging. Journal of Biomedical Science. 2019. 26:82. (Review) [ Abstract]
  39. Chuang HC and T.-H. Tan. MAP4K family kinases and DUSP family phosphatases in T-cell signaling and systemic lupus erythematosus. Cells. 2019. 8:1433. (Review) [ Abstract ]
  40. Lin HP, Ho HM, Chang CW, Yeh SD, Su YW, T.-H. Tan, Lin WJ. DUSP22 suppresses prostate cancer proliferation by targeting the EGFR-AR axis. FASEB Journal. 2019. 33:14653. [ Abstract ]
  41. Yang CY, HC Chuang, CY Tsai, YZ Xiao, JY Yang, RH Huang, YC Shih, T.-H. Tan*. DUSP11 attenuates lipopolysaccharide-induced macrophage activation by targeting TAK1. J. Immunol. 2020. 205:1644-1652. [ Abstract ]
  42. Lai CH, CC Chang, HC Chuang, T.-H. Tan, PC Lyu. Structural insights into the active site formation of DUSP22 in N-loop-containing protein tyrosine phosphatases. Int. J. Mol. Sci. 2020; 21:7515. [ Abstract ]
  43. Chuang*, H.C., M.H. Chen, Y.M. Chen, H.Y. Yang, Y.R. Ciou, C.H. Hsueh, C.Y. Tsai, and T.-H. Tan. 2021. BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Theranostics. 11: 9953-9966. [ Abstract ]
  44. Chang, C.S., Y.C. Liao, C.T. Huang, C.M. Lin, C.H.Y. Cheung, J.W. Ruan, W.H. Yu, Y.T. Tsai, I.J. Lin, C.H. Huang, J.S. Liou, Y.H. Chou, H.J. Chien, H.L. Chuang, H.F. Juan, H.C. Huang, H.L. Chan, Y.C. Liao, S.C. Tang, Y.W. Su, T.-H. Tan, A.J. Baumler, and C.Y. Kao. 2021. Identification of a gut microbiota member that ameliorates DDS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice. Cell Reports.  37:110016.                 [ Abstract ]
  45. Chuang HC, Chen MH, Chen YM, Ciou YR, Hsueh CH, Tsai CY, T.-H. Tan. 2022. Induction of interferon-γ and tissue Inflammation by overexpression of eosinophil cationic protein in T cells and exosomes. Arthritis & Rheumatology. 74:92-104. [ Abstract ]
  46. Chuang, H.C., W.T. Hung, Y.M. Chen, P.M. Hsu, J.H. Yen, J.L. Lan, T.-H. Tan. 2022. Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. Annals of the Rheumatic Diseases. 81:243-254. [ Abstract ]

    Highlighted in Lupus Foundation of America, Research News” Study Identifies New Genetic Links to Lupus“, October 6, 2021. [ link ]

  47. Chang, C.S.,W.H. Yu, C.C. Su, J.W. Ruan, C.M. Lin, C.T. Huang, C. M. Lin, Y. T. Tsai, I.J. Lin, C.Y. Lai, T.H. Chuang, W.J. Lin, T.-H. Tan, H. C. Huang, H.F. Juan, and C.Y. Kao. 2022. Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice. iScience. 25:103738. [ Abstract ]
  48. H.C. Chou, C.M. Cheng, C.H. Yang, T.Y. Lin, Y.W. Liu, T.-H. Tan, Y.R. Chen. 2022. DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction. Journal of Biomedical Science. 29:40.  [ Abstract ]
  49. Chi, J.N., J.Y. Yang, C.H. Hsueh, C.Y. Tsai, H.C. Chuang*, T.-H. Tan*. 2022. MAP4K3 inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation. Theranostics. 12:5744-5760. [ Abstract ]
  50. Chuang, H.C.*, C.H. Hsueh, P.M. Hsu, R.H. Huang, C.Y. Tsai, N.H. Chung, Y. H. Chow*, T.-H. Tan*. SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19. EMBO Molecular Medicine. 2022. 14:e15904.  [ Abstract ]

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