譚澤華 特聘研究員

[Contact Information]

Phone      +886-37-206166 Ext. 37624

Fax            +886-37-586642

Email        ttan@nhri.edu.tw

Address  3F, Bldg R1, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)

   SPECIALITY & RESEARCH FIELD OF INTEREST

   Protein Kinases and Phosphatases in T-cell Signaling, Autoimmunity, 

   and Inflammation-induced Diseases

 Tse-Hua Tan has made significant contributions to the research fields of cancer research, signal transduction, and T cell-mediated diseases. He made a seminal discovery that mutations of the tumor suppressor gene p53 lead to the activation of its oncogenic activity. In particular, Dr. Tan’s group is among the first to demonstrate the critical role of JNK in apoptosis. His highly cited paper in 1996 is the first report indicates that sustained activation of JNK is responsible for apoptosis. Dr. Tan’s team has cloned and characterized multiple novel signaling molecules particularly MAP4K family kinases (HPK1/MAP4K1, GLK/MAP4K3, HGK/MAP4K4) and protein phosphatases (JKAP/DUSP22, DUSP14, PP4) that regulate the JNK-MAPK cascade. Dr. Tan’s current research focuses on studying the roles of MAP4K family kinases and DUSP family phosphatases in T-cell signaling and inflammation-induced human diseases, particularly autoimmune diseases, cancer, and type 2 diabetes.

   EDUCATIONS AND POSITIONS 

• B.S. in Chemistry, National Taiwan University, Taipei, Taiwan (1980)
• Ph.D. in Molecular Biology (Arnold J. Levine’s Lab), Princeton University, Princeton, New Jersey, USA (1987)
• Postdoctoral Fellow (Robert G. Roeder’s Lab), The Rockefeller University, New York, New York, USA (1987-1989)
• Principal Investigator, Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research & Development Center, Frederick, Maryland, USA (1989-1992)
• Assistant Professor, Department of Microbiology & Immunology, Baylor College of Medicine, Houston, Texas USA (1992-1997)
• Associate Professor (tenured), Department of Microbiology & Immunology, Baylor College of Medicine, Houston, Texas USA (1997-2000)
• Professor (tenured), Department of Immunology (renamed as Dept. of Pathology & Immunology since 2009), Baylor College of Medicine, Houston, Texas USA (2000- )
• Director, NIH Immunology Fellowship Training Program, Baylor College of Medicine, Houston, Texas USA (2003-2012)
• Professor (joint appointment), Institute of Biotechnology, National Tsing-Hua University, Taiwan (2013- )
• Professor (joint appointment), Biological Science and Technology, National Chiao-Tung University, Taiwan (2014- )
• Founding Director, Immunology Research Center, Director, National Health Research Institutes, Taiwan (2007-2022 )
• Founding Director, Transgenic Mouse Core, Director, National Health Research Institutes, Taiwan (2010- )
• Distinguished Investigator, Immunology Research Center, National Health Research Institutes, Taiwan (2007- )

   HONORS

   SELECTED PUBLICATIONS (from more than 139 peer-reviewed papers)

      Link:

• Additional Selected Publications List
• Google Scholar : Publications and Citation

1. Ruben, S., H. Poteat, T.-H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C.A. Rosen. 1988. Cellular transcription factors and regulation of IL‑2 receptor gene expression by HTLV‑I tax gene product. Science. 241:89‑92. [ Abstract ]
2. Lai, J.-H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.-H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260-4271. [ Abstract ]
3. Chen, Y.-R., X. Wang, D. Templeton, R.J. Davis, and T.-H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and ɣ radiation: duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936. [ Abstract ]
4. Chen, Y.-R., C.F. Meyer, and T.-H. Tan. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in ɣ radiation-induced apoptosis. J. Biol. Chem. 271:631-634. [ Abstract ]
5. Hu, M.C.-T., W. Qiu, X. Wang, C.F. Meyer, and T.-H. Tan. 1996. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes & Development. 10:2251-2264. [ Abstract ]
6. Shui, J.-W., J.S. Boomer, J. Han, J. Xu, G.A. Dement, G. Zhou, and T.-H. Tan. 2007. HPK1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.  Nature Immunology.  8:84-91.  [ Abstract ]                                                                                                                                                                                           Highlighted in Nature Signaling Gateway, Signaling Update “T Cell Signaling: Giving HPK1 the SLP”,  2007 January.
7. Chuang, H.C., J.L. Lan, D.Y. Chen, C.Y. Yang, Y.M. Chen, J.P. Li, C.Y. Huang, P.E. Liu, X. Wang, and T.-H. Tan. 2011. The kinase GLK controls autoimmunity and NF-kB signaling by activating the kinase PKC-θ in T cells. Nature Immunology. 12:1113-1118. [ Abstract ]                                                                                                          Highlighted in News & Views of Nature Immunology. 12:1031-1032. [ link ]                                    Highlighted in Science-Business eXchange (SciBX). 4:42 Oct. 27, 2011                                                                        Highlighted in A-IMBN Research on 27 Dec. 27, 2011. [ link ]                                                                    
8. Li, J.P., C.Y. Yang, H.C Chuang, J.L. Lan, D.Y. Chen, Y.M. Chen, X. Wang, A.J. Chen, J.W. Belmont, T.-H Tan. 2014. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nature Communications. 5:3618. [ Abstract ]
9. Chuang, H.C., W.H. Sheu, Y.T. Lin, C.Y. Tsai, C.Y. Yang, Y.J. Cheng, P.Y. Huang, J.P. Li, L.L. Chiu, X. Wang, M. Xie, M.D. Schneider, and T.-H. Tan. 2014. HGK/​MAP4K4 deficiency induces ​TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications. 5:4602. [ Abstract ]
10. Chuang HC, CY Tsai, CH Hsueh and T.-H. Tan. 2018. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Science Advances. 4: eaat5401. [ Abstract]
11. Chuang HC, CC Chang , CF Teng, CH Hsueh, LL Chiu, PM Hsu, MC Lee, CP Hsu, YR Chen, YC Liu, PC Lyu, and T.-H. Tan. MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Research. 2019. 79:4978-4993. [ Abstract ]
12. Chuang*, H.C., M.H. Chen, Y.M. Chen, H.Y. Yang, Y.R. Ciou, C.H. Hsueh, C.Y. Tsai, and T.-H. Tan. 2021. BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Theranostics. 11: 9953-9966. [ Abstract ]
13. Chuang HC, Chen MH, Chen YM, Ciou YR, Hsueh CH, Tsai CY, T.-H. Tan. 2022. Induction of interferon-γ and tissue Inflammation by overexpression of eosinophil cationic protein in T cells and exosomes. Arthritis & Rheumatology. 74: 92-104. [ Abstract ]
14. Chuang, H.C., W.T. Hung, Y.M. Chen, P.M. Hsu, J.H. Yen, J.L. Lan, T.-H. Tan. 2022. Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. Annals of the Rheumatic Diseases. 81:243-254.  [ Abstract ]

    Highlighted in Lupus Foundation of America, Research News” Study Identifies New Genetic Links to Lupus“, October 6, 2021. [ link ]

15. Chi, J.N., J.Y. Yang, C.H. Hsueh, C.Y. Tsai, H.C. Chuang*, T.-H. Tan*. 2022. MAP4K3 inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation. Theranostics. 12:5744-5760. [ Abstract ]
16. Chuang, H.C.*, C.H. Hsueh, P.M. Hsu, R.H. Huang, C.Y. Tsai, N.H. Chung, Y. H. Chow*, T.-H. Tan*. SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19. EMBO Molecular Medicine. 2022. 14:e15904.  [ Abstract ]
17. Chen MH, HC Chuang, YC Yeh, CT Chou*, T.-H. Tan*. Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis. BMC Medicine. 2023. 21:46. [ Abstract ]